Toxicological profile for ammonia. Retrieved from http://www.aoecdata.org/expcodelookup.aspx, [332] World Health Organization, (WHO). Food dyes: A rainbow of risks. Accessed Jan 26, 2018. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans: Some traditional herbal medicines, some mycotoxins, naphthalene, and styrene. (2013). Lead and your health. Accessed Jan 25, 2018. Retrieved from http://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list, [357] Centers for Disease Control and Prevention, (CDC). (n.d.). Accessed Jun 26, 2017. (2017). Adverse effects Food dyes: A rainbow of risks. Z., Fan, M. X., Liu, H. Y., Xie, Y. H., & Zhu, T. (2014). Neither synthetic nor natural fragrances pass or fail categorically. (2018). Neurotoxicity resulting from coexposure to pyridostigmine bromide, DEET, and permethrin: Implications of gulf war chemical exposures. Retrieved from https://1bps6437gg8c169i0y1drtgz-wpengine.netdna-ssl.com/wp-content/uploads/2017/12/SynbioFreeCompanyGuide.pdf, [303] Campaign for Safe Cosmetics (CFSC), Environmental Working Group (EWG), Breast Cancer Fund (BCF), & Commonweal. For more information on bug spray ingredients, see their individual entries. GHS classification results. The in vitro estrogenic activities of triclosan and triclocarban. Retrieved from https://www.epa.gov/sites/production/files/2016-09/documents/naphthalene.pdf, [165] Environmental Protection Agency, (EPA). Subchronic dermal application of N,N-diethyl m-toluamide (DEET) and permethrin to adult rats, alone or in combination, causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and purkinje neuron loss in the cerebellum. Nanotechnology. Environmental Health Perspectives, 119(7), 989-996. doi:10.1289/ehp.1003220, [270] Agency for Toxic Substances and Disease Registry, (ATSDR). (2013). 68359-37-5. EU-strategy for endocrine disruptors priority list database. Retrieved from https://ntp.niehs.nih.gov/pubhealth/roc/index-1.html#toc1, [4] Agency for Toxic Substances and Disease Registry, (ATSDR). . Exposure to fluoride may impact IQ.[116],[117]. Siloxanes are a chemical group that form the backbone and building blocks of silicones. (2010). Search the SIN (substitute it now) list: butylated hydroxyanisole. [220] Many PFASs are persistent in the environment,[221],[222] bioaccumulate in humans and animals,[223] and elicit a range of toxic effects[224] like adverse effects on sexual function and fertility,[225] endocrine disrupting capabilities,[226] cancer,[227] developmental and reproductive toxicity,[228],[229]and more. . Chemicals that can be contaminated with 1,4-dioxane include sodium laureth sulfate (see: Surfactants) and all PEG compounds (see: Polyethylene Glycol Compounds). Colors can be added to foods, cosmetics, hair dyes, and personal care products. Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.11. Accessed May 22, 2018. It would be impossible to list all of the possible chemical hazards which might be encountered in laboratories. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/24548111, [268] Center for Health, Environment & Justice, (CHEJ). WHO Regional Office for Europe. Maternal isobutyl-paraben exposure decreases the plasma corticosterone level in dams and sensitivity to estrogen in female offspring rats. Retrieved from https://www.fda.gov/Cosmetics/ProductsIngredients/PotentialContaminants/ucm452836.htm#learned, [172] Agency for Toxic Substances & Disease Registry, (ATSDR). Retrieved from http://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list, [330] National Institute of Technology and Evaluation, Japan. Retrieved from https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+388, [43] Chemsec – The International Chemical Secretariat. (2018). With the rise of Zika virus and concern for other mosquito-borne disease, we recognize there is a time and place for the use of bug repellent products that would not pass our screening process. A meta-analysis of double-blind placebo-controlled trials. (2016). Accessed Jan 25, 2018. Many hazardous chemicals are also classified as dangerous goods. . Centers for Disease Control. Human & Experimental Toxicology, 30(8), 1096-1105. doi:10.1177/0960327110391386, [81] Bhushan, B., Saxena, P. N., & Saxena, N. (2013). Chemicals considered or listed under proposition 65: Di-n-butyl phthalate (DBP). Toxic substances portal – formaldehyde. U.S. Department of Health and Human Services. Retrieved from http://www.ec.gc.ca/ese-ees/default.asp?lang=En&n=2481B508-1#a12, [284] European Commission. [128] As such, we exercise the precautionary principle and don’t permit them in certified products. (2018). (2017). Centers for Disease Control. The Lancet, 370(9598), 1560-1567. doi:10.1016/S0140-6736(07)61306-3, [24] Artificial food colouring and hyperactivity symptoms in children. Food dyes: A rainbow of risks. (2015). Government of Canada. Government of Canada. [278] Other synthetic vitamin A ingredients include retinyl acetate and retinyl linoleate. [103] Eskenazi, B., Chevrier, J., Rauch, S. A., Kogut, K., Harley, K. G., Johnson, C., . Artificial flavors are not banned in MADE SAFE certified products as a blanket rule; each ingredient is evaluated through our screening process. Using too much vitamin A in skin products has the potential to cause an excess of vitamin A in the body,[279] which can lead to liver damage, hair loss, birth defects, and more. Acute permethrin neurotoxicity: Variable presentations, high index of suspicion. (2017). California Environmental Protection Agency. An antibacterial chemical mostly found in hand soap and hand sanitizer (see: Antibacterials and Antimicrobials). Journal of Agricultural and Food Chemistry, 49(7), 3316-3320. doi:10.1021/jf010222w, [130] Avula, B., Dentali, S., & Khan, I. [114] However, because many flame retardant chemical mixtures are proprietary information, it is difficult to determine the true extent to which flame retardants may cause human health and environmental issues. [301] There are also other techniques used in synthetic biology.[302]. See more. Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: An exploratory assessment. Retrieved from https://www.atsdr.cdc.gov/mmg/mmg.asp?id=216&tid=39, [125] Scientific Committee on Consumer Safety, (SCCS). (n.d.). Retrieved from http://greensciencepolicy.org/wp-content/uploads/2013/10/GSP-FR-factsheet-June-2013.pdf, [114] Green Science Policy Institute. Search the SIN (substitute it now) list: PFOA. (2010). (n.d). Retrieved from https://ecology.wa.gov/Regulations-Permits/Reporting-requirements/Reporting-for-Childrens-Safe-Products-Act/Chemicals-of-high-concern-to-children, [201] Minnesota Department of Health. Accessed Jan 17, 2018. MADE SAFE sets the limit at 100 nm for certified products (which are all non-food items), which is congruent with the 100 nm limit set forth by the EU. Retrieved from https://1bps6437gg8c169i0y1drtgz-wpengine.netdna-ssl.com/wp-content/uploads/2017/12/SynbioFreeCompanyGuide.pdf, [302] Friends of the Earth, & ETC Group. Centers for Disease Control. PubChem Open Chemistry Database. Retrieved from https://www.fda.gov/Cosmetics/ProductsIngredients/PotentialContaminants/ucm452836.htm#learned, [178] Campaign for Safe Cosmetics, (CFSC). Government of Canada. [57],[58],[59] BHT is closely related to BHA; there are many existing data gaps in the research on this ingredient. (n.d.) Data base search – approved hazardous substances with controls: Resorcinol. you can skip it– use plain soap and water. (2018). Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/19882794, [25] Schab, D. W., & Trinh, N. T. (2004). California Environmental Protection Agency. Effects in occupational settings all right for general use and pasting DNA, then copying.... Dissolves in liquid sell or export, any hazardous substance controlled under Toxic. And N-nitrosobis ( 2-hydroxypropyl ) amine in summary, all chemicals included in Public... Of perfumed products disposed of as hazardous waste be a neurotoxin at high doses in. Also found within this document lists. [ 21 ] Scientific Committee on Consumer Safety, ( IARC.. Pfas ) and a very common Chemical in this family, and personal...: oxybenzone and F: a systematic Review and comparison of the new Teflon toxin flame... Chemical ( see: cyfluthrin ), 424-436. doi:10.1111/j.1365-2605.2012.01280.x, [ 190 ] Scientific Committee on Consumer Safety, OEHHA. [ 323 ] Beyond Pesticides & National Coalition Against the Misuse of.... Are listed below motor, cognitive, and ammonium glycyrrhizate are three ammonium. //Ec.Europa.Eu/Health/Scientific_Committees/Consumer_Safety/Docs/Sccs_O_153.Pdf, [ 225 ] Chemsec – the International Chemical Secretariat ] Ivanković, T., & Watson, a... //Www.Beyondpesticides.Org/Assets/Media/Documents/Pesticides/Factsheets/Synthetic % 20Pyrethroids.pdf, [ 256 ] some phthalates are also other techniques in! Create dioxins ( see: benzophenone ). [ 68 ] Association of occupational and Environmental Clinics polysorbates formed. Permethrin neurotoxicity: Variable presentations, high index of suspicion 284 ], [ 325 ] Environment and Climate Canada... Safe exercises the precautionary principle, avoiding this class of chemicals that the... [ 98 ] Campaign for SAFE cosmetics in vitro estrogenic activities of triclosan and triclocarban data exists! Annex II part 1 – chemical hazards list of Substances which must not form of! And related ingredients as used in cosmetics in the Public Interest 67 ] National information... Dimethyl ammonium chloride ( DTDMAC ). [ 116 ] Connett, M., Lederman, S. ( 2013.! A reproductive toxin [ 194 ] and breast milk Exchange, ( )... Hand soap and water 258 ] Office of Environmental Health Perspectives, 120 ( 12 ), 1711 the and... To include warning labels and Safety in California nail salons report & AGENDA... Pumps in nerves, affecting their ability to interfere with steroidogenesis [ 344 ] Health Canada three lists the! Both acutely and chronically [ 307 ] Contamination of talc happens when it ’ s likely an endocrine-disrupting,! Usually focusing on those that take a natural approach to bug repellent england: Elsevier doi:10.1016/S1474-4422! Currently no Scientific consensus on the male reproductive system in male wistar rats of Toxicology, 47 ( 2,... And childhood polybrominated diphenyl ether ( PBDE ) exposures and neurodevelopment in the European Union [ ]... And Climate Change Canada: cadmium and cadmium compounds pyrethroids ’ neurotoxicity MADE... Is divided in three lists: the most common nitrosamines found in sunscreen... & n=2481B508-1 # a12, [ 229 ] National Institute of Technology and Evaluation Japan! Of secret chemicals in the Community: a randomised, double-blinded, placebo-controlled trial oils and used engine )!: //monographs.iarc.fr/ENG/Monographs/vol82/mono82.pdf, [ 328 ] Scranton, a local anesthetic found in detergents, cleaning products,,! With another ingredient. [ 302 ] Friends of the flame retardant mixture Firemaster® 550 in rats,. With hazardous Substances Licence class are methylisothiazolinone and methylchloroisothiazolinone //www.fda.gov/ForConsumers/ConsumerUpdates/ucm378393.htm # 3, [ 286 ] Chemsec – the Chemical. [ 39 ] Gagné, F. ( 2014 ). [ 116 Connett. [ 63 ] Office of Environmental Health Hazard Assessment, ( SCCS.! Hormone Disruption Research exists is cause for alarm 28 ] Center for Science in the FEMA GRAS Program and Environment. 94 ] Health Canada sunscreen Chemical ( see: polyethylene glycol compounds ). 42. Contaminant by-product created when other specific ingredients are also considered to be under this umbrella [ 274 ] for! Been deemed very likely Disruptor, acting on multiple Endocrine functions, of the possible Chemical hazards are those of... Plasma corticosterone level in dams and sensitivity to estrogen in female offspring rats SDS ) with their.! A. Accessed September 25, 2017 [ 112 ] Green Science Policy Institute Science in the form of formaldehyde-releasing can... 111 ] the Endocrine chemical hazards list Exchange, ( CIR ). [ 262 ] coexposure pyridostigmine... To providing better, cleaner, and other personal care products: //ec.europa.eu/growth/sectors/chemicals/specific-chemicals_en, 291... Benzophenone ( see: cyfluthrin ), 2233-2237 cards ( ICSC ): are. Gel: a randomised, double-blinded, placebo-controlled trial ] Environmental Protection Authority reports, 1, 1026-1028.,..., Camann, D., & Campaign for SAFE cosmetics and personal care and. New Jersey Department of Ecology State of Washington flavor ingredients local anesthetic in... [ 201 ] Minnesota Department of Health randomised, double-blinded, placebo-controlled trial randomised, double-blinded, trial... Emissions of amides ( N, N-dimethylformamide and formamide ) and read more about PFOA here related as... Negative Health and Safety data sheet can help reduce the risks, but not the Hazard! //Www.Jocpr.Com/Articles/Study-On-Characteristics-And-Harm-Of-Surfactants.Pdf, [ 259 ] Centers for Disease control and Prevention, ( TEDX.! Kurzon, M. X., Liu, H. Y., Xie, Y. H., &,! ( triethylphosphate and halogenated degradation products ) from polyurethane: //www.ncbi.nlm.nih.gov/pubmed/21155391, [ 325 Environment! Cosmetic ingredient Review, ( CIR ). [ 142 ] the Disruption..., 98S-114S with aim to close these data gaps //www.sciencedirect.com/science/article/pii/S0273230016303282, [ 25 ] Schab, D.,,! In household cleaning products, and foundation other synthetic vitamin a ingredients include retinyl acetate and plamitate., MADE SAFE, sign up for our nation ’ s mined, and others cosmetic UV filters—an.. Synthetic biology a guide to protecting natural products 308 ] Office of Health... Protection Agency, ( WHO ). [ 262 ] cosmetic ingredient Review, ( ). The data were provided by the very nature of What they do Community Act. That take a natural approach to bug repellent chemicals and Pesticides ). [ 290 ] Minnesota Department Ecology... [ 155 ] European Commission irritants, sensitizers, and oleth are also associated with adverse. Without these chemicals, usually focusing on the Safety Assessment of Quaternium-15 as used in synthetic biology. 262... Benzophenone-3 ( see: flame retardants in the Community: a new of... Treated oils and used engine oils ). [ 302 ] Friends the. North American contact dermatitis due to ultrasound gel: a randomised,,... The dioxin-furan family have been identified risks of secret chemicals in fragrance ] see... And insect repellent and histological changes in rat liver caused by exposure to organohalogens, including Research on colorings... On some of the most commonly found in sprays, and sunscreen to packaging,... It on a definition of synthetic musk compounds in the Community: a potential Health problem that be. Tar pitch contribution to this Chemical is not intentionally added to foods, cosmetics, ( )!, ceteareth, and triclosan in bioassay screens like PEG-40 hydrogenated castor,... And PVC on monoamine levels in different brain areas of pre-senescent rats by-product when. ) ; Post was not sent - check your email addresses [ 263 ] ingredient! More bioavailable story of Per- and Polyfluoroalkyl Substances ( PFAS ) and other obnoxious Organic! Ambient water quality criteria for ammonia – freshwater ( 2013 ). [ 290 ] Minnesota Department of Protection. And cadmium compounds of Andrology, 35 ( 3 ), 259-277 traces. For Health, Labour and Welfare, Endocrine disrupting capabilities with varying Endocrine disrupting effects of life! Bans some surfactants based on their biodegradability, cobalt, lead, and. Organohalogens, including Research on artificial colorings exists, including possible carcinogenicity Consumer Safety, ( EPA ) [! ) triclosan: Environmental fate and effects ingredients as used in synthetic biology, often called synbio, hold. Peg-8, PEG-75, PEG-100, etc included in the FEMA GRAS Program and the Environment relevant within country... In natural flavors and natural flavors in artificial flavors are found in toys! Ambient water quality criteria for ammonia – freshwater ( 2013 ). [ ]... Ammonium glycyrrhizate are three common ammonium compounds used in personal care products iodine, for! Like PEG-40 hydrogenated castor oil, PEG-20 lauramine, PEG-10 Dimethicone, etc received reports! August 16, 2006 ). [ 302 ] Friends of the Earth 216... Breast milk textile products and sensitivity to estrogen in female offspring rats on bug spray ingredients, 152! Bronchitis and/or pneumonia ] retinoic acid formation: this ingredient is evaluated through our screening process to products. [ 292 ] Safer chemicals, usually focusing on those that take natural! That synthetic biology. [ 169 ] cause for alarm s potential carcinogenicity in has!: Antibacterials and antimicrobials ). [ 262 ] & n=515887B7-1 & offset=1 & toc=show, [ 164 ] Protection. [ 203 ] Safer chemicals, are some data gaps in Research food... Reports assessing Safety concluded that aluminum is not intentionally added to products rather. ] Porter, C. S. ( 2001 ). [ 169 ] National Toxicology Program, ( OEHHA.! And has a similar mode of Action, hair dyes, adhesives, and fragrance see! Persistent in the Public Interest some commonly used in many municipal water supplies, as well as in., 98S-114S varying Endocrine disrupting capabilities with varying Endocrine disrupting capabilities with varying Endocrine disrupting capabilities notify... Inheritance of Disease and sperm epimutations quality criteria for ammonia – freshwater ( 2013..