What is Arsenic . Print. two kinds of poisoning have been identified by the national safety, Poisoning - . Arsenic has been used since 3000 BC. | PowerPoint PPT Chronic arsenic poisoning is due to repeated or continuous exposure to arsenic compounds, which leads to an accumulation of arsenic in the body. atomic number:33 element symbol:as element name:arsenic atomic mass:75. Long-term everyone reacts differently. Presented by: Nirojan Balachandran Saranga Sreeskantharajan Kimberly Stobo Tian Qi Wang. Lead (Pb) has been used by humans for at least 7000 years, because it is widespread, easy to extract, and easy to work with. summarized the environmental behaviour of arsenic, with particular emphasis on sources, distribution, and accumulation of arsenic in the Australianence of used : rat poison found: food, water. Welcome to Click to edit Master subtitle style ARSENIC POISONING Click to edit Master subtitle style Amir Sadaula (01) Arjun Pandit (02) Bikas Puri (03) Bishwo Bandhu Pokharel (04) by, jeremy rubert. Arsenic - . the poison of kings. Arsenic poisoning 1. arsenic is a solid, liquid , and a gas!. If you continue browsing the site, you agree to the use of cookies on this website. (2011). We have tried to make it as attractive, brief and informative as possible. You can change your ad preferences anytime. arsenic poisoning in tube. PHM142H1-F October 9, 2013. Contaminated water used for drinking, food preparation and irrigation of food crops poses the greatest threat to public health from arsenic. See our User Agreement and Privacy Policy. New technologies require behavioral change on the part of the user, thus Arsenic poisoning in Bangladesh Fluorosis • Tooth discoloration and decay • Crippling skeletal damage Arsenicosis • Skin pigmentation changes and skin thickening (hyperkeratosis) • Cancer of … Re-cently, Smith et al. He was admitted 5 h later. Arsenic poisoning( acute, subacute and chronic) 1. 2,8,18,5. information. Arsenic poisoning acts on different metabolic pathways of glucose metabolism. (2013). Slide 7- ppt slide no 7 content not found poisoning. morgan dunn stevie turner. There are more than 8,000 villages in Bangladesh where more than 80 percent tube-wells are arsenic poisoning. What Distribution • The largest quantity of arsenic is found in the liver. poisoning. Arsenic - Laura stanton. Arsenic is present as a contaminant in many traditional remedies. Arsenic is a natural component of the earth’s crust and is widely distributed throughout the environment in the air, water and land. SOS-Arsenic: Private Iniciative against Poisoning of Ground Water in Bangladesh The arsenic hazard in Bangladesh villagers now appeared as a ‘real disaster', affecting thousands physically, physiologically, mentally and economically; it is intensifying malnutrition, … http://dx.doi.org/10.1155/2013/219840 Sullivan, John B. and Gary R. Krieger. Arsenic toxicity and potential mechanisms of action. 25 year old vietnamese lady unable to communicate due to language, Arsenic Poisoning in tube wells in bangladesh - By: lauren jones & david pinigis. Summary Exposure to heavy metals such as mercury, lead, iron, and arsenic is harmful to the human body and can potentially cause both acute symptoms (e.g., local irritation, gastroenteritis, and pneumonia) and longterm effects (e.g., abnormal physical development, cancer, damage to the central nervous system, and kidney). food sources. p.861-864. reactor shut down!. Alsevier Inc. Rosen, B. Arsenic toxicity and methods of detection. Now customize the name of a clipboard to store your clips. Arsenic is a natural semi-metallic chemical that is found all over the world in groundwater. Absorption • Soluble and acidic arsenic compounds are readily absorbed in the stomach • Inorganic Arsenic compounds can also be sequestered on mucosal linings, leading to irritations and a concentration gradient that aids in the absorption of Arsenic compounds. Arsenic poisoning, or arsenicosis, happens when a person takes in dangerous levels of arsenic. Cancer Research. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. However, symptoms of chronic arsenic poisoning from ingestion of contaminated water are typically observed only after 10 or more years of exposure. The three main sources of exposure are occupational exposure, natural contaminants of drinking water (from some deep water wells) and ancient Chinese medicinal remedies containing arsenic. loveland tech4good luke whitaker / may 27, 2014. arsenic detection techniques. PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson. Arsenic Poisoning. not anticipated! o vervie w. efficiency chemical structures uses problems, Poisoning - . -3. If arsenic poisoning occurs over a brief period of time, symptoms may include vomiting, abdominal pain, encephalopathy, and watery diarrhea that contains blood. elment info. small systems implementation strategy & exemptions. Arsenic. belongs to family number 15 has 5, Mercury and Arsenic poisoning - . Wayne State University School of Medicine [PDF Document]. Acute Poisoning: Symptoms of acute intoxication usually occur within 30 minutes of ingestion but may be delayed if arsenic is taken with the food. Natural Arsenic Levels Crystalline Rock Soil Ground Water Surface Water Avg. Diagnosis of arsenic poisoning is made by determining inorganic and organic levels of arsenic in the blood and urine. 74.92106. Treatment of arsenic poisoning in acute toxic poisonings needs to begin quickly; treatment involves removal of arsenic by dialysis , chelating agents, replacement of red blood cells , and if ingested, bowel cleansing. as. Metabolism • Main organ for arsenic metabolism is the liver, Metabolism continued Step 1 • Inorganic pentavalent arsenate is reduced to trivalent arsenite in the blood stream before entering the cells • Can occur non-enzymatically in the presence of a thiol such as glutathione (GSH), Metabolism continued Step 2 • Methylation to monomethylarsonic acid (MMA) and to dimethyl- arsinic acid (DMA) is enzymatic, requiring S- adenosylmethionine (SAM) and a methyltransferase • MMA and DMA are excreted in the urine (thousandfold less-potent as mutagenic agents than inorganic arsenic) • Methylation has long been considered the main route of detoxification, but there is growing literature supporting other methods such as transport and antioxidant defenses, Mechanism of Action of (As3+) • Reacts with thiol-containing molecules (R-SH) • Arsenite inhibits GSH Reductase by interacting with critical thiol groups • Blocks production of GSH (glutathione, important antioxidant) causing increased free radicals and oxidative damage • Increased production of ROS such as superoxide radical, singlet Oxygen, hydroxyl radicals, hydrogen peroxide, Mechanism of Action of (As3+) • Inhibits lipoicacid (a dithiol) which is an important cofactor for Pyruvate Dehydroxygenase (PDH) • As [Acetyl CoA] decreases  Citric Acid Cycle activity decrease, causing: • Decreased ATP production • Decreased Gluconeogenesis (synthesis of glucose from carbohydrates, fatty acids, proteins, etc) Function of PyruvateDehydroxygenase: Oxidize Pyruvate to Acetyl CoA before Citric Acid Cycle Arsenic binds to Lipoid Acid-PDH to form 6-member ring Lipoic Acid-PDH, Arsenate resembles Inorganic Phosphate Competitively inhibits phosphate for active site in G3P-Dehydroxygenase Replaces phosphate in many biochemical reactions in cellular respiration ATP ADP-arsenate (arsenolytic mechanism – uncouples ATP formation) Glucose-6-Phosphate  Glucose-6-Arsenate Glyceraldehyde-3-Phosphate  Glyceraldehyde-3-Arsenate Mechanism of Action of (As5+) Inorganic Phosphate is chemically similar to Inorganic Arsenate, Inhibition of Glyceraldehyde-3-Phosphate dehydrogenase, Arsenic is a Carcinogen • Associated with oxidative stress, cell arrest in the G2/M phase, chromosomal abnormalities, and DNA aneuploidy. © 2020 SlideServe | Powered By DigitalOfficePro, - - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -. Journal of Applied Toxicology. group 15, metalloid (category/group) germanium, gallium, it sublimates, Arsenic - . Clipping is a handy way to collect important slides you want to go back to later. 62:3893-3903 Mcintyre, D, O. Linton, T, K. (2011). 31:95-107. Patient went into shock and finally was admitted in the ICU
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. A 43-year-old male attempted suicide in July, 2001, by drinking 54 g of arsenic trioxide (As2O3). Arsenic - . structures, physical and chemical properties, Poisoning - . poisons. Arsenic as a Global Pollutant - Arsenic as a Global Pollutant Tiffany Berg March 26th, 2011 Health effects of arsenic poisoning Keratosis Internal tumors Cancers of the skin, liver, bladder, and lungs. On arrival he was pale and diaphoretic, but his vital signs were normal. 1. • Metabolized to toxic form of As3+ , MMA(III) before entering cells • ADP forms ADP-arsenate instead of ATP; Glucose-6-Arsenate instead of G6P; Glyceraldehyde-3-arsenate instead of G3P. jonathan kernaghan. Poisoning - By kristin hoffpauer , courtney maccallum , sarah plante , sammi pedigo. Toronto: Oxford UP, 2009. peter worcester a period. Arsenic, element 33, has a long and nefarious history; its very name has become synonymous with poison. A patient was bought to the Emergency ward with history of rashes and blebs all over his skin mainly on his arms and feet. Talanta, 58, 201-235. http://dx.doi.org/10.1016/S0039-9140(02)00268-0 Miller, W., Schipper, H., Lee, S., et al. • Recommended treatment is Dimercaptosuccinic acid (DMSA). • Arsenic depositions in the brain and spinal cord can lead to developmental disabilities, and cognitive impairments. +5. why is it called arsenic?. Physical Properties. arsenic - . Clinical Environmental Health and Toxic Exposures, Lippincott Williams & Wilkins; 2 edition (June 4 2001). claire m. waggoner aquatic toxicology. Guide to Nutritional Supplements. As 33 74.99. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. 2 ppm 1-40 ppm 0.01 – 800 ppb As high as 40,000 in hot springs 2.38 – 65 ppb Some Arsenic Uses/Anthropogenic Sources • Smelting of metals Retrieved from Lecture Notes Online Website: http://mstc.csmu.edu.tw/ezcatfiles/mstc/img/img/466/961008-BarryPhilipRosen.pdf Sears, M. E. (2013). Looks like you’ve clipped this slide to already. USES: primarily in the production of glass and semiconductors, in wood and hide preservation, as an additive of metal alloys In the past arsenic was used as weed killer, rodenticide, in chemical warfare pigments and enamels. arsenic. Arsenic round the world: a review. 149, Arsenic-Gallium - . dr esther tsang august 2011. case 1. poisoning. prepared by muhammad hashim. Mechanism of arsenic poisoning Adrian Bumstead, Xiao Qi Li, Jessica So, Jin (Donna) Yang PHM142 Fall 2015 Instructor: Dr. Jeffrey Henderson Overall - try to keep the text to a minimum (the presentation guideline for the cardio Arsenic is highly toxic in its inorganic form. A 47-year-old man had an episode of severe respiratory failure after acute intoxication with arsenic. APIdays Paris 2019 - Innovation @ scale, APIs as Digital Factories' New Machi... No public clipboards found for this slide. Long-term exposure to arsenic can also lead to cancer, possibly affecting the lungs, bladder and China lead poisoning(2009) Zamfara lead poisoning(Mar-June 2010): About 163 deaths due to illegal extraction of ore by villagers in Anka & Bukuyyum LGA’s. It is the common environmental toxicant and is found in soil, water, and air. Your advice would be useful in perfecting our future slides. this element's name was derived from " arsenikon. Contamination is caused by arsenic from natural geological sources leaching into aquifers, contaminating drinking water and may also occur from mining and other industrial processes. Mandal, B. K., & Suzuki, K. T. (2002). This a special article from Telugudoctors.co.in; Hope you find it useful and informative. Symptoms of arsenic poisoning, or arsenicosis, can include skin lesions, swollen limbs and loss of feeling in the hands and legs. substance which when introduced into body in relatively small amounts causes in structural damage, Arsenic Rule - . 33. Arsenic - . Dr Kaleem Khan Assistant Professor JNMCH 2. Toxicology Letters 133:1-16 Jomova, K., Jenisova, Z., Feszterova, M., Baros, S., Liska, J., Hudecova, D., Rhodes, C.J., Valko, M. (2010). A patient was bought to the Emergency ward with history of rashes and blebs all over his skin mainly on his arms and feet. What causes chronic arsenic poisoning? Features of the initial clinical presentation included nausea, vomiting, and diarrhea, acute psychosis, diffuse skin rash, and marked pancytopenia. poisoning. atomic number is 33 atomic mass is 75 family: 15 nitrogen. sources . A brief presentation on Arsenic poisoning encompassing 40 slides - also included is a quiz on toxicology at the end. danger rangers video. The patient, a chemist by profession, prepared this amount of arsenic trioxide in his factory laboratory using a commercial solution of arsenic trichloride (AsCl3) as a base. Presented by: Nirojan Balachandran Saranga Sreeskantharajan Kimberly Stobo Tian Qi Wang. Arsenic: toxicity, oxidative stress and human disease. Arsenic Poisoning - Free download as Powerpoint Presentation (.ppt / .pptx), PDF File (.pdf), Text File (.txt) or view presentation slides online. properties. – A free PowerPoint PPT presentation (displayed as a Flash ARSENIC POISONING A. As 33 74.99. • Carcinogenic due to oxidative stress, inhibition of p53, genotoxicity, altered DNA repair mechanisms and tumor promotion • “Arsenite” - Trivalent (As3+): Reacts with reacts with thiols and sulfhydryl groups • Inhibits GSH Reductaseblocks of GSH production Oxidative stress and production of free radicals • Inhibits Pyruvate Dehydroxygenase decreased activity in Citric Acid Cycle decreased ATP production and Gluconeogenesis • “Arsenate” - Pentavalent (As5+): replaces phosphate groups because of similar molecular structure). It acts on glycolysis, TCA cycle and on Pyruvate dehydrogenase complex. acute toxicity acute, short, severe course, adverse effects occurring within a short time of, Arsenic - . The Scientific World Journal, 2013, 13 Pages. albertus magnus (1193-1280), a german philosopher and theologian, was the first to state that arsenic has a, Arsenic - . As attractive, brief and informative tiffany goulart grey or yellow or black, poisoning.... 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